Drug Development Meets Advanced Materials Processing

Hand with sanitary gloves check Medical vials on product.


In the rapidly evolving pharmaceutical industry, the quest for more efficient drug development processes has never been more critical. Precision materials processing stands at the forefront of this transformation, offering revolutionary methodologies that enhance drug formulation and delivery systems. This post explores how advanced materials processing technologies are reshaping drug development, spotlighting the role of high-shear mixers and homogenizers in achieving unparalleled precision and efficiency.

The Challenge of Traditional Drug Development

Traditional drug development faces numerous challenges:

  • Lengthy development times
  • High costs
  • Ensuring consistent drug quality and efficacy

Key Study: One pivotal study by DiMasi, Grabowski, and Hansen (2016) highlighted the escalating costs and timelines associated with bringing new drugs to market, underscoring the need for more efficient methodologies (Journal of Health Economics, 47, 20-33).

The Solution: Advanced Materials Processing Technologies

High-Shear Mixers and Homogenizers:

Enter high-shear mixers and homogenizers—cutting-edge tools designed to streamline pharmaceutical manufacturing, allowing companies to:

  • Streamline pharmaceutical manufacturing
  • Facilitate rapid mixing and dispersion
  • Enhance drug uniformity and stability

Key Study: A study by Smith et al. (2018) demonstrated that high-shear processing improves solubility and bioavailability of poorly water-soluble drugs (International Journal of Pharmaceutics, 536(1-2), 123-139).

Case Study: Revolutionizing Drug Formulation

Example: Consider the development of a new cancer treatment drug using high-shear mixers which resulted in:

  • Homogeneous blending of APIs with excipients
  • Optimized drug delivery mechanism
  • Expedited development phase
  • Higher reproducibility and scalability

This process not only expedited the drug’s development phase but also ensured a higher degree of reproducibility and scalability for mass production.

FlackTek™’s Contribution to Tribochemical Synthesis Discoveries

FlackTek’s involvement in advancing tribochemical synthesis techniques through collaboration has led to:

  • Rapid synthesis rates of pharmaceutical cocrystals
  • Reduction in synthesis time from hours to minutes
  • Maintenance of product integrity

Key Study: A landmark study Teoh et al. (2022) highlighted FlackTek™’s technology in achieving rapid tribochemical synthesis (Angewandte Chemie International Edition).  FlackTek™’s technology was utilized to achieve unprecedented synthesis rates of pharmaceutical cocrystals based on the active pharmaceutical ingredients (APIs) carbamazepine, dihydrocarbamazepine, and nicotinamide, showcasing a reduction in synthesis time from hours to minutes without compromising the product’s integrity.

The Impact on Drug Development and Patient Outcomes

The implications of integrating precision materials processing into drug development are profound.


  • Reduced time-to-market for critical medications
  • Enhanced drug performance
  • Improved patient outcomes
  • Precise control of drug formulation processes
  • Compliance with stringent regulatory standards


Advanced materials processing technologies represent a pivotal step forward in drug development. By embracing these innovations, we can streamline processes and significantly impact patient care, ushering in a new era of pharmaceutical manufacturing characterized by efficiency, precision, and unparalleled quality.